Pilot test of intranasal oxytocin as an enhancer of brief couples therapy for posttraumatic stress disorder

  • Sippel, L. M., Khalifian, C. E., Knopp, K. C., Webster, K., Maglione, J Holcomb, J...Morland, L. A. (2023). Pilot test of intranasal oxytocin as an enhancer of brief couples therapy for posttraumatic stress disorder. Journal of Psychiatric Research, 161, 165-169. https://doi.org/10.1016/j.jpsychires.2023.03.001
  • Brief cognitive-behavioral conjoint therapy (bCBCT) is an 8-session treatment for couples where one partner has posttraumatic stress disorder (PTSD). This study examined an adaptation of bCBCT, adding intranasal oxytocin (bCBCT + OT), which helps regulate stress and fear and can facilitate trauma recovery and relationship functioning. 10 Veterans with PTSD and their partners (N = 10 couples) completed baseline, posttreatment, and 3-month follow-up assessments, as well as a weekly assessment during treatment. Overall, bCBCT + OT appeared to be a feasible, acceptable, and effective treatment for improving PTSD symptoms and relationship functioning.

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